SCORE stands for SCrum fOr REsearch.
It is an specific implementation of the popular software development project management methodology to the world of research teams.
In a previous post, I introduced a slideshare presentation dealing with the use of agile management in science. The pdf document I introduce to you today is going the same way by showing how Scrum could be adjusted to manage research groups. I’ll let you make your own opinion on it and let you give me some feedbacks or comments you could have.
Personnally, I plan to start the online learning process of scrum, offered freely by the Scrum101 project.
Here is the link to the SCORE introduction : http://www.cs.umd.edu/~mwh/papers/score.pdf
Drug discovery is a major research field nowadays, mostly due to the need it answers. And this new program is in my opinion a major step forward, as it brings a new method not based on lottery.
By “lottery”, I mean that the whole current process starts with a gamble we play by assuming that a given set of chemical groups would be included in the ideal candidate.
After that, we enter in the world of statistical chemistry, by combining a limited but large range of molecules bringing the wanted groups in the mix. Then starts a long data mining and chemical tests, which can be quickly expensive in terms of time, human resources and money.
The idea here is not to “lock” the protein’s action but to change its shape. Yes, “change its shape”. The concept is so simple : a protein’s activity is governed by its 3D shape. So, if a protein doesn’t work well, we have to reshape it to a correct form and it will do his duty.
All the difficulty was to be able to produce such molecular structure able to shapeshift proteins. And that’s where this team, led by Dr Mark Dufton, succeeded.
Let’s hope that some applications will soon be developed. At least, it’s a door opened to a whole new vision of drug discovery and understanding of the human body’s natural regulation processes.